Archive for 2006

Adiponectin, fat distribution and insulin resistance

Wednesday, December 20th, 2006

Adiponectin, a peptide hormone that is secreted from fat cells, appears to be part of the fat distribution puzzle. Subjects with higher adiponectin had less insulin resistance and lower waist circumferences. Moderate weight loss did not change adiponectin levels...so the fat distribution signal was still in place. Injections of adiponectin have ...

Oxidative stress associated with visceral fat

Tuesday, December 19th, 2006

High levels of visceral fat are associated with greater oxidative stress and the metabolic syndrome (syndome x). Even non-obese subjects exibited an association between visceral fat and oxidative stress. It is unclear if antioxidants might partially reverse syndrome x. It is clear that those with visceral fat accumulation should eat more ...

Strength training and hormones

Monday, December 18th, 2006

Non weight trainers were put on a 3 day a week strength training program. Immediately after strength training, there was a decrease in androgens and a decrease in the anabolic/catabolic hormones ratio. After the recovery, there was an increase in androgen levels...especially epitestosterone. The increase in androgens correlated with increases in ...

Carbohydrates during high intensity exercise does not raise insulin levels

Friday, December 15th, 2006

Runners where put through an intense bout of interval training and received either carbohydrates or a placebo. Interestingly, no differences in plasma insulin, cortisol or free fatty acids were observed. The carbohydrate group did achieve higher lactate levels during exercise, which could indicate a supression of fat burning or just a ...

Leptin injections kill fat cells

Thursday, December 14th, 2006

Rats given leptin injections had increased fat cell apoptosis (cell death) in both peripheral fat deposits and in bone marrow. The leptin pathway is more complicated in humans than in rats, but future drugs may be able to partially duplicate this in humans. Abstract Related posts:Leptin decreases fat pad deposits independent of norepinephrine Leptin, ...

Triglycerides correlated with insulin resistance and visceral fat

Wednesday, December 13th, 2006

It is well known that the metabolic syndrome is accompanied by high blood triglycerides. But do high levels of these blood fats cause metabolic syndrome or are they a symptom of it? Rabbits bred to be hypertriglyceridemic had more visceral fat and greater insulin resistance. Improving insulin sensitivity improves both triglycerides ...

DHT and visceral fat

Tuesday, December 12th, 2006

Menopausal women experience a shift in fat distribution from a female pear shape to a more male-like apple shape due to visceral fat accumulation. It has been speculated that a shift in androgen to estrogen ratio was a principal cause. This was confirmed by this study which showed DHT, the most ...

ALT liver enzyme a marker for insulin sensitivity

Monday, December 11th, 2006

ALT is a liver enzyme commonly measured in liver panel lab tests. It also appears to be a marker for insulin sensitivity. It is also a very cheap lab test, compared to oral GTT or HbA1C. An elevated ALT is associated with reduced insulin sensitivity and glucose tolerance and increased triglycerides. Abstract Related ...